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Molecular characterization of TGF? mediated cancer cell proliferation

 

Marketed By :  VDM Verlag Dr. Müller   Sold By :  Kamal Books International  
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  • Product Description
 

TGF? has a dual role in carcinogenesis, acting as a growth inhibitor in early tumor stages and a promoter of cell proliferation in advanced diseases. Although this cellular phenomenon is well established, the underlying molecular mechanisms remain elusive. Here, we report that sequential induction of NFAT and c-Myc transcription factors is sufficient and required for the TGF? switch from a cell cycle inhibitor to a growth promoter pathway in cancer cells. TGF? induces the expression and activation of NFAT factors, which then translocate into the nucleus to promote c-Myc expression. In response to TGF?, activated NFAT factors bind to and displace Smad3 repressor complexes from the c-Myc promoter. c-Myc in turn stimulates cell cycle progression and growth through up-regulation of D-type cyclins. Most importantly, NFAT knockdown not only prevents c-Myc activation and cell proliferation, but also partially restores TGF-beta-induced cell cycle arrest and growth suppression. Taken together, this study provides the first evidence for a Smad-independent master regulatory pathway in TGF?-promoted cell growth that is defined by sequential transcriptional activation of NFAT and c-Myc factors.

Product Specifications
SKU :COC13164
AuthorDr. Garima Singh,Dr. Shiv Kishor Singh and Prof. Dr. Volker Ellenrieder
LanguageEnglish
BindingPaperback
Number of Pages100
Publishing Year2010-04-11T00:00:00.000
ISBN978-3639298017
Edition1st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandVDM Verlag Dr. Müller
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-22 00:00:00