Category

share

Molecular Mechanisms of C-CBL on Cytoskeleton-mediated Phenomena

Molecular Mechanisms of C-CBL on Cytoskeleton-mediated Phenomena

 

Marketed By :  Scholars' Press   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 
₹ 5,953

Availability: Out of stock

 

Delivery :

5% Cashback on all Orders paid using MobiKwik Wallet T&C

Free Krispy Kreme Voucher on all Orders paid using UltraCash Wallet T&C
Product Out of Stock Subscription

(Notify me when this product is back in stock)

  • Product Description
 

c-Cbl functions as a multifunctional adaptor and an E3 ubiquitin protein ligase. Several studies have shown that c-Cbl is involved in cytoskeleton-mediated events , but the molecular mechanisms linking c-Cbl to cytoskeletal rearrangements remain to be elucidated. To understand the role of c-Cbl in regulation of cytoskeleton-dependent cellular functions, we assessed the roles of endogenous Rac1, RhoA and Rap1 in the c-Cbl-dependent spreading and migration of v-Abl-transformed fibroblasts overexpressing c-Cbl, using RNAi. Glioma invasion is involved in multiple biological processes which are primarily associated with cytoskeleton-mediated events including adhesion, migration, and degradation of extra cellular matrix (ECM). In this study, we examined biological roles of c-Cbl using RNAi-mediated depletion of endogenous c-Cbl and stably c-Cbl expressing glioma cells generated by lentiviral transduction and showed that c-Cbl increases invasion through degradation of ECM by upregulation of MMP2 but not through migration, adhesion, or growth of SNB19 glioblastoma cell line.

Product Specifications
SKU :COC61030
Country of ManufactureIndia
Product BrandScholars' Press
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05
0 Review(s)