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Molecular Regulation of the Exocytic Mode in Adrenal Chromaffin Cells

 

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  • Product Description
 

Neuroendocrine chromaffin cells of the adrenal medulla are a primary output for the sympathetic nervous system. Chromaffin cells release catecholamine as well as vaso- and neuro-active peptide transmitters into the circulation through exocytic fusion of large dense-core secretory granules. Under basal sympathetic firing, chromaffin cells selectively release modest levels of catecholamines, helping to set the “rest and digest” status of energy storage. Under stress activation, elevated sympathetic firing leads to increased catecholamine as well as peptide transmitter release to set the “fight or flight” status of energy expenditure. While the mechanism for catecholamine release is widely studied, relatively little is known of how peptide transmitter release is regulated to occur selectively under elevated stimulation. This work investigated the role cytoskeletal elements and molecular motors play in the regulation of transmitter release from chromaffin cells. In summary, an intact actin cortex is required for modest release of catecholamines, while dissolution of the actin cortex and concomitant activation of mysoin II results in the increased transmitter release.

Product Specifications
SKU :COC43119
AuthorBryan Doreian
LanguageEnglish
BindingPaperback
Number of Pages292
Publishing Year2010-10-04T00:00:00.000
ISBN978-3843359191
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-01-08 00:00:00
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