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Molecular Signaling Pathways in Human Skin Carcinogenesis


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The delta isoform of Protein Kinase C (PKC-?) is a potential tumor suppressor gene for human squamous cell carcinomas (SCCs). The objective of this study is to investigate the mechanism of PKC-? loss in human SCCs. We used Laser Capture Microdissection to isolate cells for nucleic acid analysis from normal epidermises and human SCCs. Using this approach, we found that PKC-? is lost at the mRNA level in human SCCs, and that the PKC-? gene is rarely deleted suggesting that the mechanism of down-regulation of PKC-? in SCCs is at the level of gene transcription. Further investigation identified a novel Ras?PI3K?Fyn?NF-?B signaling pathway necessary and suffcicient for PKC-? repression in human keratinocytes. Our results have implications for the development of therapeutic strategies abrogating this signaling pathway to trigger the re-expression of pro-apoptotic PKC-? to induce apoptosis in SCCs.

Product Specifications
SKU :COC94628
AuthorVipin Yadav and Mitchell F. Denning
Number of Pages192
Publishing Year2011-07-19T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00