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mTOR activates PKB/Akt and PKC-α in Cardiac Hypertrophy


Marketed By :  AV Akademikerverlag   Sold By :  Kamal Books International  
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  • Product Description

Many people are suffering from cardiac hypertrophy, which can lead to heart failure. The numbers of patients, who are dying because of heart failure, are increasing. Therefore it is important to understand the underlying molecular mechanism of this disease. In cardiac hypertrophy the heart tries to catch up with the increased afterload by increasing the proteinbiosynthesis and cell growth making its ventricular walls thicker. In the beginning, the adaptation is physiological and reversible. This state is called compensated. But it can turn pathological, when the stress is too high and chronic, making the heart unable to fulfill its duty. In this decompensated state the heart fails to pump enough blood through the body, what can finally lead to congestive heart failure. Mammalian target of rapamycin (mTOR) is a key signaling molecule in cell growth and can be blocked by rapamycin. By blocking mTOR it could be possible that the hypertrophy of the heart can be blocked. The ideal case would be that only the pathological and not the physiological changes in the heart are blocked. In my study I investigated the signaling pathways of mTOR in relationship to cardiac hypertrophy.

Product Specifications
SKU :COC87090
AuthorLudwig Villiger
Number of Pages72
Publishing Year2013-01-18T00:00:00.000
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandAV Akademikerverlag
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00