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Multitarget inhibitors for TryS, TryR and TryP in Leishmania donovani


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The present study focuses on multi target inhibitors search based on proteins of Trypanothione pathway. For this we had modelled TryS, TryR and TryP proteins using Homology modelling and validated, based on which docking calculations were done. In the next step, active sites were explored to allow compounds to dock. Finally, we screened common hits amongst these protein targets. Top compounds were validated and their ADME profiles were also predicted. Some ligands shown good Glide Gscore in all three protein Targets. Interaction profiles can be further utilized to build computational novel structures. The further work needed to fit the hits molecules in assays to validate hits and refine or optimize the hit molecules.

Product Specifications
SKU :COC31445
AuthorVIKAS GAUTAM,Ganesh C. Sahoo and Pradeep Das
Number of Pages108
Publishing Year2012-10-08T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00