Present work aimed to evaluate the protective effect of L-carnitine and/or N-acetyl cysteine (NAC) on CCl4-hepatotoxicity. Male albino rats were classified into 8 groups. Group I: normal control group. Group II: treated with L-carnitine. Group III: treated with NAC. Group IV: treated with L-carnitine and NAC. Group V: received CCl4 and served as cirrhotic control group. Group VI: treated with L-carnitine and CCl4. Group VII: received CCl4 and treated with NAC. Group VIII: treated with L-carnitine, NAC and received CCl4. Samples are collected and parts of the livers are preserved for histology. Results showed that treatment with CCl4 induced a significant increase in serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities, plasma sialic acid, total bilirubin, nitrite levels, and liver lipid peroxide content. Also, it induced a significant reduction in plasma albumin level, liver total protein, glutathione, and vitamin C contents. In the present study, it could be noticed (from the treatment with L-carnitine and NAC) that there were pronounced improvements in all studied parameters. We recommend a collective combination of L-carnitine and NAC.