Theoretical evaluation of the innovative flotation technology was employed using specially designed apparatus to study the nanobubbles stability and the roles of nanobubbles on particle-bubble interactions, froth stability, and surface area flux. In addition, a detailed technical performance and economic evaluation was performed. Nanobubbles integrated into a specially designed column flotation expanded the particle size range for efficient froth flotation as a result of increased probabilities of particle-bubble collision and attachment and reduced probability of detachment. The major advantages of nanobubble enhanced flotation include lower collector and frother dosages. Also, nanobubbles act as a secondary collector on particle surfaces, thereby resulting in considerably lower operating costs.