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Nanoparticles, to enhance bioavailability of anti-diabetic drug


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

In this book stable nanoparticles of pioglitazone HCL were prepared using biodegradable polymer, to increases bioavailability and to control release of drug. PGZ is used for the treatment of diabetes mellitus type 2. The drug modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscular tissues and in the liver. It is an activator of the intracellular peroxisome proliferator-activated receptor-γ, and decreases metabolic and vascular insulin resistance causing rise in HDL-cholesterol plasma in humans. However, the poor aqueous solubility of PGZ may cause low bio absorption and limited therapeutic efficacy. So, the aim of the present study was to prepare stable PGZ loaded polymeric nanoparticles, to enhance the solubility and improve the bioavailability of the drug.

Product Specifications
SKU :COC87713
AuthorKuldeep Joshi,Bhoomika Joshi and Shobhana Menon
Number of Pages52
Publishing Year2013-09-19T00:00:00.000
Edition1 st
Book TypeChemistry
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00