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Nanoparticulate drug delivery of an anticancer drug


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

This book is about formulation and evaluation of methoxy polyethylene glycol epsilone polycaprolactone (MPEG-EPCL) nanoparticles containing Gemcitabine hydrochloride. Gemcitabine is a nucleoside analogue, used in treatment of various carcinomas such as non small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. The major setbacks to the conventional therapy with Gemcitabine include its short half-life and highly hydrophilic nature. Gemcitabine loaded (poly-e-caprolactone)-methoxy poly(ethylene glycol) copolymers that were used for the preparation of nanoparticles with the objectives to sustained the drug release, to increase plasma circulation half life of drug, to reduce the dosage frequency, to overcome high dose related side effects of Gemcitabine hydrochloride and to prevent opsonization by PEGylation and to evaluate the particle size and entrapment efficiency, in vitro release and stability for the treatment of pancreatic cancer. Methoxy Polyethylene Glycol-Epsilone Polycaprolactone (MPEG—EPCL) nanoparticles containing Gemcitabine hydrochloride were prepared by double emulsion(w/o/w)-solvent evaporation methodology.

Product Specifications
SKU :COC60503
AuthorParagkumar Patel,Megha Patel and Rajesh K.S.
Number of Pages168
Publishing Year18.09.2014
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00