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Natural Killer Cells and Hepatitis C Virus


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Innate immunity is thought to contribute to sustained virological response (SVR) to pgylated interferon-?/ribavirin (peg-IFN-?/ribavirin) therapy. Natural killer (NK) cells are implicated in the regulation of a protective immune response in patients chronically infected with HCV. We sought to investigate the level of NK subsets among Egyptian patients with chronic HCV and to analyze the influence of IFN therapy on this level. Samples were collected from chronically infected patients (n= 37) at baseline and from a subset before and after 6 months on peg-IFN-?/ribavirin therapy. NK cells were characterized by flow cytometry. The number of CD3- CD56+ cells was significantly lower in patients with chronic HCV infection before treatment compared to healthy controls, but they increased during IFN therapy. There was a significant increase in the number of CD16+ and CD3- CD56+ cells in patients with sustained virological responses (SVR) during therapy compared to patients are non-responders (NR). Meanwhile, CD56+ cells were significantly increased in patients with chronic HCV infection before treatment compared to healthy controls and decreased during therapy in responders.

Product Specifications
SKU :COC61013
AuthorNoha Mahana,Somaya El-Deeb and Mona Hassouna
Number of Pages88
Publishing Year29.08.2014
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00