1-Phenylnaphthalene and Pericarbonyl lactone lignans are synthesized by green chemistry and the lignans having similar 1-Phenylnaphthalene skeleton are extracted from two plants-Ruta graveolens Linn. and Jatropha gossypifolia Linn using soxhlet assembly.These natural and synthetic lignans were then tested for their immunomodulatory potential. Starting with β-benzoyl propionic acid and aryl aldehydes, α-arylidine-γ-phenyl-∆,β,γ-butenolides were synthesized. The lactone ring of butenolides is opened to get the keto acid i.e. α-arylidine-β-benzoyl propionic acid. Cyclization of above keto acid as well as its derivatives with sulphamic acid catalyst under microwave radiation ultimately lead to 1-Phenylnaphthalene systems. The immunomodulatory activity of the 1-Phenylnaphthalene systems is studied by the two methods–“Spleen cell proliferation” and “Effect on serum immunoglobulins”. It is found to be quite significant in both synthetic compounds as well plant extracts. The findings suggest that 1-Phenylnaphthalene lignans can positively modulate the immunity of the host.