Dengue is one of the major health problem in many countries. Aedes aegypti mosquito is the major vector of dengue fever disease. Search for larvicidal active compound(s) is one of the several attempts to find effective and affordable ways to control this mosquito. In this study investigated the toxic effect of different solvent (acetone, chloroform, cold and hot ethanol) extracts from different parts (bark, leaf, root and seed) of Neem (Azadirachta indica) against Aedes aegypti larvae. Therefore, this study demonstrated the potency of Neem in managing the larvae and thus contribute as an affordable way to control Aedes aegypti mosquito. Through this study the crude extracts from different parts of Neem (Azadirachta indica) could be extracted by using different solvents and this will lead to different biological activities.