Large output signal is the main bottleneck for the design of a low noise and low power neural amplifier used in a bio-potential acquisition system. This book critically focused on the design and simulation of single electrode array low noise low power neural amplifier for biomedical/Neural signal recording application. Specifically, it is intended to be used in the front-end of a biomedical signal processing block. In this book design of a low power low noise neural amplifier has been discussed with special emphasis given on the optimization of parameter such as noise, power and output swing. For low power and low noise pMOS input transistor and weak inversion topology has been used. Neural amplifier structure used to record signals like Electroencephalography (EEG) Electromyography (EMG, consist of two stage, in the first stage a low noise opamp of 60db used for noise reduction and in the second stage a band pass filter (BPF) which is also act as Programmable Gain amplifier (PGA) is used to get variable gain. This book also discussed a novel Pseudo resistor structure to get tunable cutoff frequency.