There is no dearth of books entitled with Pharmacology, Neuropharmacology, Behavioral Pharmacology, and so on. But this book on Neuropharmacology has its own unique features in its way of presenting the concepts of the Metabotropic Glutamate Receptors in very lucidly and simple manner, which does not demand much effort from the reader to gain insights. The past three decades have highlighted the evolution of Glutamate as an important excitatory neurotransmitter in the vertebral nervous system. This book emphasizes on finding the role of Metabotropic Glutamate Receptors (mGluRs) in synaptic facilitation and depression in controlling synchrony of the oscillatory activities produced by the neurons by the pharmacological manipulation of the presynaptic Metabotropic Glutamate Receptors in the theta, beta and the gamma frequency ranges. The data thus indicate that pharmacological manipulations of the presynaptic receptors will affect the network activity and synchrony in the medial entorhinal cortex (mEC).