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Neuroprotective Role of Quercetin and Etodolac against AD

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Animals were exposed to Aluminium chloride at a dose of 4.2 mg/kg/day B.W. for 28 days followed by a post treatment with Quercetin which was administered at two dose levels 25 and 50 mg/kg/day B.W. for 28 days and similarly Etodolac which was administered at 20 and 40 mg/kg/day B.W. for 28 days on different groups. Another post treatment with combination of both drugs at lower dose levels was carried for 28 days period. Memory assessment of animals was examined by step down behavioral memory testing apparatus on every 7th day of the study. oxidative stress was recorded from estimation of stress markers after aluminium chloride exposure. Brains isolated were carried for histopathology.Animals were sacrificed & subjected to biochemical estimation where a significant p<0.001 increase in GSH, SOD (plasma and RBC) and AchE levels & significant p<0.001 decrease in LPO levels were observed in the groups treated with individual drugs at different dose levels. However highly significant decrease in LPO and increase in AchE, GSH and SOD & decrease in LPO were observed with the combination of Quercetin and Etodolac at 25 and 20 mg/kg/day B.W. were observed with histopathology of the brain.

Product Specifications
SKU :COC84915
AuthorSarabjeet Singh,Ramandeep Singh and Ramandeep Kaur
LanguageEnglish
BindingPaperback
Number of Pages120
Publishing Year2013-01-02T00:00:00.000
ISBN9783659316296
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00