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NFκB signaling in different stages of intestinal carcinogenesis

 

Marketed By :  Südwestdeutscher Verlag für Hochschulschriften   Sold By :  Kamal Books International  
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  • Product Description
 

Colorectal cancer remains one of the major health concerns as it is the 2nd most common cause of cancer deaths in developed countries including more than 1 million new diagnosed cases each year. Risk factors are mostly conditioned by environmental influences but also by chronic inflammation. The transcription factor NF-κB is known as the key factor involved in inflammation and has been shown to be constitutively active in most cancers and inflammatory pathways activated in cancer. However, the complex mechanisms and the celltype and context specific functions of NF-κB remain poorly understood. This book aims to contribute to a deeper comprehension of NF-κB and its role in colorectal cancer. Here, NF-κB is demonstrated to be substantially involved in cell type plasticity during tumor initiation as well as during tumor progression. During tumor initiation NF-κB triggers Wnt-dependent dedifferentiation of enterocytes leading to cell transformation calling attention to dedifferentiation as a novel cell-of-origin concept in cancers. During late tumor stages, NF-κB supports epithelial-mesenchymal-transition and is responsible for the recruitment of an inflammatory microenvironment.

Product Specifications
SKU :COC84132
AuthorSarah Schwitalla
LanguageEnglish
BindingPaperback
Number of Pages196
Publishing Year2013-10-16T00:00:00.000
ISBN9783838135182
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandSüdwestdeutscher Verlag für Hochschulschriften
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00