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NITRIC OXIDE-DEPENDENT STRESS MODULATION BY WITHANIA SOMNIFERA

 

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  • Product Description
 

Withania somnifera (Ashwagandha, Indian ginseng) roots powder has been studied that it acts as an antidepressant on central nervous system. However, the mechanisms underlying its antidepressant effect is poorly understood. NO, neuromodulator produced by nNOS from its precursors and like L-Arginine can be inhibited by its inhibitors like L-Cystenine. To elucidate the mechanism of Withania somnifera, we investigated the effect of a powdered root of Withania somnifera (WS) on nitric oxide (NO) production in Wistar rats. We found that WS produced a significant and concentration-dependent increase in NO production. Biochemical data from Lowry's method gave the protein content and NOx assay gave the nitrate/nitrite content during restraint stress. The results indicate a possible involvement of NO in stress-induced neurobehavioral effects.

Product Specifications
SKU :COC16413
AuthorZaved Khan
LanguageEnglish
BindingPaperback
Number of Pages84
Publishing Year2010-03-08T00:00:00.000
ISBN978-3838377780
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-25 00:00:00
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