Category

share

Non-infectious CXCR4-tropic HIV induces T-Cell death and possibly AIDS

Non-infectious CXCR4-tropic HIV induces T-Cell death and possibly AIDS

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 
₹ 4,396

Availability: Out of stock

 

Delivery :

5% Cashback on all Orders paid using MobiKwik Wallet T&C

Free Krispy Kreme Voucher on all Orders paid using UltraCash Wallet T&C
Product Out of Stock Subscription

(Notify me when this product is back in stock)

  • Product Description
 

A gradual decline in CD4 T-Cells is the main hallmark of HIV infection. At the "T-Cell inflection point", there is an accelerated CD4 T-Cell decline and the onset of CD8 T-Cell decline, leading up to Aquired Immune Deficiency Syndrome (AIDS). Strains of HIV that can bind the CXCR4 co-receptor emerge prior to this, suggesting that they contribute to immune failure by inducing death in naive, CXCR4-bearing T-Cells. Naive T-Cells are critical for replenishing the immune system after any kind of T-Cell loss. Additionally, the vast majority of HIV virions circulating during infection are defective and non- infectious. Their effects on immune cells are not clearly understood. In this study, primary peripheral blood T-cells were exposed to inactivated, non-infectious, HIV-1 virions. The study shows that when T-cell subsets were purified and isolated from each other, CXCR4- tropic virions induce a significantly greater decline in the number of naive, CD4 T-cells as opposed to the CCR5-tropic strains which initiate HIV infection (P=0.013). The emergence of CXCR4-utilizing HIV virions later on during infection may therefore contribute to the development of AIDS.

Product Specifications
SKU :COC28474
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-29
0 Review(s)