Platelet alterations in diabetes in general are similar to those seen in non-diabetic patients with atherothrombic diseases so it is not clear whether these platelet alterations are due to Diabetes Mellitus or as a consequence of vascular disease. The predictive relation between Diabetes Mellitus and platelets was observed in association with CVD and CBD. A sample based study including 100 Diabetic patients was carried out in Gujrat, out of which 59 were suffering from CVD and 12 had CBD. Among the subjects 50% patients had high blood platelet count. A significant (p>0.05) higher BP, BMI and Hypertension was found in Diabetic patients of both sexes. After adjusting for the effects of risk factors including age, BP, cholesterol level, obesity, smoking habits and persons with personal history of heart attack, heart failure or stroke relative risks for heart and brain stroke mortality and morbidity were not significant (p<0.05) in this study.