The development in genetic engineering has led to a proliferation of wide variety of proteins, which are administered by parenteral route and in majority of the cases, chronic therapy of these peptides and proteins is warranted. The inherent problems to parenteral protein delivery are patient compliance (repeated injections due to the short half-life which is highly discomfort). To address these problems a great deal of research is being carried out to develop painless and convenient methods for delivery of proteins and peptides utilizing the approaches of novel drug delivery systems. Current work discusses the nasal delivery approaches and research carried out during the past few decades for non invasive insulin delivery. To achieve this goal, nasal route has proved to be the most convenient and practical route of administration. Major barriers to develop nasal formulations for peptide/proteins are discussed.