In this book a new generation of smart adaptive control design that can lend itself into a system- centric controller is proposed. A system-centric controller could perform case-based control with respect to changing system dynamics unlike other controllers. To this end, a new class of intelligent adaptive control for systems with complex and multi- modal dynamics including scheduled and scheduled 'Jumps', is developed. Those systems are often under the challenge of unforeseen changes due to wide range of operations and/or external influences. The underlying structural feature is the introduction of Intelligent Supervisory Loops (ISL's) to augment conventional controller(s). The main emphasis is to design ISL's to enhance controllers acting in one domain so that based on system complexities this architecture can evolve from a static to an intelligent controller or smart controller. Four such novel design formulations are developed which evolved from different methods of conceiving ISL's. These designs are tested with comprehensive simulation models of a robotic manipulator, a fighter aircraft and a modern power system system.