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Novel iron chelators for iron overload disease and cancer treatment

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Iron (Fe) chelation therapy involves the use of drugs that avidly bind Fe from biological systems. Iron chelators were developed for the treatment of Fe overload diseases, B-thalassemia and Friedreich''s ataxia. However, the increased requirement for Fe in rapidly proliferating cancer cells, compared to normal cells, makes Fe a target for cancer chemotherapy. Iron chelators remove Fe from Fe-containing proteins, including ribonucleotide reductase, a key enzyme involved in the rate-limiting step of DNA synthesis and inhibit proliferation. Chelators with potent antiproliferative activity also demonstrate the ability to form Fe complexes that redox cycle. This leads to the generation of reactive oxygen species which induce DNA oxidation and mitochondrial damage. The investigations described in this book detail several structural features involved in targeting ligands for either the treatment of Fe overload disease or cancer chemotherapy. These findings emphasise the importance of donor atom identity and inductive effects on the redox cycling and antiproliferative activity of aroylhydrazone, thiohydrazone and thiosemicarbazone Fe chelators.

Product Specifications
SKU :COC16891
AuthorDanuta Kalinowski and Des R. Richardson
LanguageEnglish
BindingPaperback
Number of Pages288
Publishing Year5/14/2010
ISBN978-3838300283
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-25 00:00:00