Strategic considerations and security concerns continued to influence the study of the nuclearization of South Asia. The Indo-Pak struggle for the deterrent capability has always been in conflict with the norms as well as the writ of the global nonproliferation regime that encompasses several treaties, extensive multilateral and bilateral diplomatic agreements, multilateral organizations and domestic agencies, and the domestic laws of participating countries. The non-proliferation regime lacks the instruments which are universally acceptable. In case of South Asian nuclearization, nuclear acquisitions were somehow dependent on the international non- proliferation regime which has been moderated by the interests of great powers, especially the Cold War blocks and their policies subject to the nonproliferation. Regional conflicts further intervened and proved to be benefiting South Asian nuclear desire. The main objective of this monograph is to highlight the issues that have challenged the writ of global non-proliferation regime.