Being profitable and competitive is always a priority for firms regardless of the sizes. The quest for productivity and excellence performance has forced firms to look internally into many factors. Firms are bound to minimize risks that incur operation costs such as high scraps inventory. The use of Occupational Safety and Health (OSH) practices in manufacturing operations is now recognized as a competitive advantage in eliminating the non-added value or minimizing the interruptions to the production process to enhance firm performance. This monograph highlights the empirical investigation on the Occupational Safety and Health (OSH) practices toward operational performance in Malaysia manufacturing sector.