The gait characteristics between patients with knee osteoarthritis (OA) and a control group, and the efficacy of a 6-month progressive resistance training (PRT) program on dynamic alignment during gait in OA patients, a randomized into experimental and a sham-exercise control group is investigated in this book. Knee adduction moment (KAM) was not greater in the OA group compared to the controls. The OA group walked with increased shank adduction angle. Quality of life, level of habitual physical activity, muscle strength and balance were impaired in the OA group. In the second experiment, dynamic alignment of the OA group measured by knee and shank adduction angles did not improve following the intervention. Resistance exercises together with reduced bone-on-bone forces, pain, and difficulty provided against a range of motor control strategies by Which functional performance improved. The postural differences in the gait pattern could be due to the factors examined as local alignment and degeneration location and these factors should be taken into consideration for future studies.