Osteoporosis is a common metabolic bone disease and although creates health problems mainly in older women, but the etiology of osteoporosis largely begins at a younger age. Therefore prevention of this disease is top on the agenda of many health initiatives worldwide. Improving knowledge, attitude and health behaviors is the first-line effective strategy for prevention. Thus in a community-based experimental study we evaluated the effectiveness of an educational osteoporosis program based on the Health Belief Model on knowledge, beliefs and practice (exercise)among a sample of Iranian young female. Participants in the intervention group were exposed to a three months educational program. Osteoporosis knowledge, health beliefs, and total time (min) and frequency of weight-bearing exercise in the past seven days were assessed at baseline, and at the end of three months follow up. This book indicates that an effectiveness osteoporosis educational program can help to improve Iranian young female knowledge, beliefs and regular exercise as a health prevention action for osteoporosis.