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P-glycoprotein and the development of multidrug resistance

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The development of drug resistance during the therapy is a major obstacle in the successful treatment of various pathologies. The in vitro studies on cell lines have shown that exposure to a single drug often leads to a cross-resistance to several other structurally and functionally unrelated compounds. This phenomenon is known as multidrug resistance (multidrug resistance, MDR). The membrane transporters play a role in the absorption, distribution and elimination of metabolic products, of ions and of most drugs. The membrane transporters include a variety of membrane proteins with different structures and functions, such as, for example, exchangers of ions and proteins from the ABC family (ATP-binding cassette). Importance of the membrane transporters appears from genetic diseases that are caused by alteration of their functions. Although the role of membrane transporters in the drug effects aroused a particular interest in the recent years, the relevant transporters remain still unknown to most drugs. Even though it is known that a specific transporter interacts with a drug, there is the possibility that the unidentified transporters to recognize the same drug.

Product Specifications
SKU :COC54466
AuthorNicolae Alina
LanguageEnglish
BindingPaperback
Number of Pages112
Publishing Year2014-11-07T00:00:00.000
ISBN9783659634499
Edition1 st
Book TypeLaw
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-06-08 00:00:00