Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

p50 NF-κB and Dendritic Cells: a matter of life and death

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 3,651

Availability: In stock

 
  • Product Description
 

Already 10 years ago, p50, a regulatory subunit of the NF-κB family of transcription factors was shown to accumulate in the nucleus of LPS tolerant cells. More recently, the group of Antonio Sica has shown that accumulation of p50 homodimers in the nucleus of Tumour Associated Macrophages results in defective expression of proinflammatory cytokines (TNF-α, IL-12) and reduced IL-10 production, correlating with increased tumour growth. Moreover, p50 accumulation in the nucleus of macrophages is an essential event for promoting endotoxin tolerance and pro-tumour polarized functions in these cells. Given the important role of p50 in controlling tolerance in innate immunity (macrophages), we wondered if p50 accumulation in Dendriic Cells could mediate their activation versus tolerant activity over adaptive immunity.

Product Specifications
SKU :COC87112
AuthorPaola Larghi,Chiara Porta and Antonio Sica
LanguageEnglish
BindingPaperback
Number of Pages88
Publishing Year2013-02-22T00:00:00.000
ISBN9783659280849
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00