The research is aimed to find out Pakistan and the United States of America relations. I intended to find out the historical events highlighted significant issues in the relations between two countries. The current status of the relations has also been highlighted. Important events regarding various issues will helpful to understand the status of cooperation and conflict between two states. A policy recommendation can therefore serve as an important tool for the future consultation and citation. It will also provide the probable direction of Pak-U.S. relations in the future challenges and opportunities. The focus has been on the objectivity of research and analysis on the basis of keeping in view all the possible aspects of the situation in discussion.