An experimental study has been carried out for pyrolysis oil and diesel blend was used in single cylinder, 4-stroke diesel engine. Pyrolysis oil is obtained from tire waste by pyrolysis process. Pyrolysis process is a therm-o-chemical decomposition of organic matter in absence of oxygen. Blending of pyrolysis oil with diesel helps to reduce the consumption of diesel fuel. Diesel engine is already optimized for particular fuel i.e. diesel. So, it does not give optimum performance for pyrolysis and diesel blend. In this study, parameters i.e. load, blend proportion and injection pressure were taken as variable for optimization. Optimization of these three parameters is done by DOE (Taguchi Method), which gives optimum performance for given bland.