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PHARMACOKINETICS AND BIOAVAILABILITY OF SILYMARIN

 

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  • Product Description
 

Silymarin is a purified extract from milk thistle (Silybum marianun (L.) Gaertn), composed of a mixture of isomeric flavonolignans: silybin (its main, active component), isosilybin, silydianin and silychristin. This extract has been empirically used as a remedy for almost 2000 years, and remains being used as a medicine for many types of acute and chronic liver diseases. Despite its routinely clinical use as hepatoprotectant, the mechanisms underlying its beneficial effects remain largely unknown. The purpose of this study was to investigate the pharmacokinetics and bioaequivalence of two brands of Silymarin tablets in healthy male volunteers in local population. Pharmacokinetic parameters were calculated by non- compartmental method using Kinetica® PK/PD version 4.4 and MS Excel Windows professional XP. Maximum concentration of Silymarin in plasma (Cmax), time to these peak plasma concentrations (Tmax) and other bioparameters (AUC0-?, AUMC0-?, t1/2, Ke, MRT, Vd and ClT) were determined.

Product Specifications
SKU :COC95027
AuthorMuhammad Usman,Mahmood Ahmad and Asadullah Madni
LanguageEnglish
BindingPaperback
Number of Pages136
Publishing Year2011-01-20T00:00:00.000
ISBN978-3844300048
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00
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