Abstract: The aim of the present study was to assess the anti-fertility activity of ethanolic extracts of Tabernaemontana divaricata (TD) leaves in estrogenic activity models in immature female rats. Mature green leaves of TD were collected and authenticated. Extractions of the dried leaves were carried out with ethanol in a Soxhlet’s apparatus. For estrogenic activity, the extracts were administered orally once daily at a dose of 200 and 400 mgkg1, and the activity was compared with the standard drug ethinyl estradiol(0.02 mg). The extracts caused ignificant increase in uterine weight compared to the control. The ethanolic extract exhibited estrogenic activity. The histological study of epithelium tissues with the 400mg of TD extract-treated animals showed increases in the height of the luminal epithelium and loose edematous stroma when compared with the 200 mg of TD extract-treated group of animals. However, this was better than the control group of animals. Enhanced uterine weight and increase in the height of luminal epithelium and histological characteristics suggest that TD extract may be useful in anti-fertility therapy.