Disinfectants act at a fundamental level in infectious disease control, by eradicating pathogens responsible for both clinical and sub-clinical infectious diseases from poultry housing . Disinfection has proven to be the most Cost-effective to Infectious Disease Control, and can be readily adapted to any Infectious Disease challenge in any environment. Disinfectants offer a much broader spectrum of protection relative to antibiotics and vaccines, without the likelihood of leaving harmful chemical residues in the meat and eggs.Disinfectants offer a very broad spectrum of protection against pathogenic organisms that includes bacteria, viruses, fungi and yeasts. A wide choice of Chemo-disinfectants is available, with diverse properties suitable for poultry industry. Both iodophors and quaternary ammonium compounds possess both cleaning (highly effective in dirt penetration and removal) and powerful disinfection properties thus allowing a single-step sanitisation especially in water sanitation.