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Platelet Alloantibody


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The frequency of platelet-specific antibodies in multitransfused patients and their implication in platelet transfusion refractoriness has been a matter of controversy for years. The main reasons are the difficulties encountered in differentiating between HLA- and platelet-specific antibodies and, within platelet-specific antibodies, between auto- or alloantibodies, using the available platelet antiglobulin test. In the recent years, capture assays were developed, using immobilized platelet membrane glycoprotein (GP) carrying the antigens under investigation to avoid using whole platelets. These assays overcome the difficulties in differentiating platelet-reactive antibody mixtures and allow determination of antibody specificity. For the group of highly HLA-immunized patients in need for HLA-matched single donor platelets, however, there are only as many as 25% will have additional platelet-specific alloantibodies. These platelet-specific alloantibodies will prohibit satisfactory transfusion results if HLA-matched but HPA-incompatible platelets are transfused.

Product Specifications
SKU :COC30123
AuthorWan Haslindawani Wan Mahmood,Rapiaah Mustafa and Wan Soriany Wan Mohd Zain
Number of Pages64
Publishing Year3/27/2012
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-29 00:00:00