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PLGA-BASED NANOPARTICLES IN CANCER IMMUNOTHERAPY AND IMMUNOMONITORING

 

Marketed By :  VDM Verlag Dr. Müller   Sold By :  Kamal Books International  
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Rs. 5,066

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  • Product Description
 

Anti-cancer immunotherapy is an emerging approach to enhance endogenous tumor-directed immune responses. Dendritic cells (DCs) are of particular interest in this regard due to their exclusive role in cell- mediated immunity. Using versatile poly(D,L-lactic- co-glycolic acid) (PLGA) nanoparticles, multiple vaccine components can be delivered to DCs in a protected and sustained-release manner. Active targeting of DCs in vivo using PLGA nanoparticles decorated with either receptor ligands or specific antibodies can enhance uptake, processing and presentation of antigens to T lymphocytes resulting in immnuostimulation. This opens up novel approaches in nanomedicine for design of cancer vaccines. Since significant progress in cancer vaccination requires immunomonitoring during immunotherapy, PLGA nanoparticles are promising vehicles for directing the molecular imaging probes towards DCs to map their way after being internalized. This approach may elucidate the dynamic of DC activation, fate, DC- T cell interaction in lymph nodes and tumor cells. This vital information would assist in development of vaccine strategies to shift the balance in favour of immune system.

Product Specifications
SKU :COC94998
AuthorZahra Ghotbi
LanguageEnglish
BindingPaperback
Number of Pages168
Publishing Year2011-02-18T00:00:00.000
ISBN978-3639275599
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandVDM Verlag Dr. Müller
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00