Sequence analysis, phylogeny, modeling, energy minimization, drug design, toxicity, binding affinity and PCP. Geneious Pro, ADMET, Modeller, FlexX and LigPlot. DHFR, Oxamide, Peganum harmala, Pneumocystis carinii, Binding affinity, Docking and Antimicrobial activity. Lung, Spleen, Liver and also the Eye. Fungi mediated Parasite. ZINC Database, Library creation. Klebsiella pneumonia, Pseudomonas aeruginosa and Candida albicans.