In the last few years, there has been a significant increase in population growth all over the world, particularly in the developing world. This has been accompanied by intensive urbanization, increased industrial activities and a greater exploitation of forested and cultivable land. These transformations have provoked a large increase both in the quantity of discharge and the range of pollutants that could reach the river waters and have undesirable effects both on fish and fisheries. River Kabul is the source of drinking, watering live stock, irrigation and fishing for million of people in Pakistan and Afghanistan. River Kabul is used as a source of live lihood for thousands of fishermen living along the bank of the river. A tremendous fish decline has been occurred in the recent past as been reported by the Fisheries Department of the Province. Aim of study was to quantify the quality and quantity of pollutants casing havoc in the inhabitant fish population. For this purpose a study was carried out by the Department of Zoology, University of the Punjab to sort out the remedy.