Today many medicinal plant species of India have reached the fate of extinction of severe toxicity of liver and kidney. Unfortunately detailed information and complete inventions on such plats often do not exist. For most of the endangered species, no conservation efforts have been implemented and a lion’s share of the knowledge on their properties and use are held exclusively by traditional healer societies, whose very existence is now under threat. The aim of this book in the study of ploygonum bistorta is a herbal plant is used against over doses of paracetamol toxicity in liver and kidney. The crude extract of root and active compound (tannic acid) of polygonum bistorta plant showed hepatoprotective activity. This book describes antioxidant activity, blood, tissue biochemical as well as histopathological study of liver and kidney against toxicity of paracetamol. We believe that this book is one of the pioneering compilations of extract and active compound of herbal plant which are very protective mechanism in toxicity liver and kidney organs. This book will be useful to the people interested in medicinal properties of polygonum bistorta and its treatments.