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Polymeric Nanoparticles for Efficient in vitro Gene Delivery


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

With the continuous influx of knowledge about the role of genes involved in acquired or hereditary diseases, the delivery of regulatory genes or nucleic acids into affected cells is a potentially promising strategy. During the past few decades, a large number of systems have been explored to modify the biodistribution and bioavailability of biomolecules by using carrier systems such as liposomes, micelles and nanoparticles. Amongst various nanoparticles prepared from polycationic polymers, polyethylenimine (PEI) takes a prominent position due to its high transfection efficiency owing to its endosomal escape potential. To date, a large number of studies regarding incorporation of modifications into PEI to improve upon the gene transfer efficacy have been proposed. However, the problems of toxicity and poor gene delivery efficiency associated with PEI poses a major hurdle for in vivo studies. The work embodied in thesis started with the purpose of incorporating suitable modifications into PEI to improve in vitro transfection efficiency and cell viability. Suitable chemical modifications resulted in several folds improvement in transfection efficiency and reduction in cytotoxicity.

Product Specifications
SKU :COC58158
AuthorSurendra Nimesh
Number of Pages156
Publishing Year2012-05-21T00:00:00.000
Edition1 st
Book TypeTechnology: general issues
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-06-08 00:00:00
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