Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

Population Pharmacokinetics of Phenytoin in Epileptic Patients

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 3,651

Availability: In stock

 
  • Product Description
 

Phenytoin exhibits non-linear pharmacokinetics, narrow therapeutic index, marked inter-individual variations and causes wide variety of adverse effects which warrants the need for monitoring. The present study was taken up to monitor serum concentrations and to carry out preliminary pharmacokinetic modelling. HPLC method was standardized to estimate the serum concentration of phenytoin. Blood samples were withdrawn from the patients after the steady state has been reached. In the study period of 8 months, 20 patients were enrolled out of whom, 10 patients received oral phenytoin whereas 10 were given IV infusion. It was observed that there were a lot of variations in the PHT serum concentrations in different patients with peak values ranging from 5.11 to 80.59 µg/ml and trough concentrations ranging from 1.06 to 92.10 µg/ml. However seizure was well controlled in all the patients with no major toxicities observed. Preliminary population pharmacokinetic modelling was attempted using NONMEM, due to small sample size a robust model could not be developed that gives a definite correlation between the variables and pharmacokinetic parameters.

Product Specifications
SKU :COC95058
AuthorRamjan Shaik and Shobha Rani R hiremath
LanguageEnglish
BindingPaperback
Number of Pages88
Publishing Year2011-03-29T00:00:00.000
ISBN978-3844323085
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00