The present investigation captioned “Potentials of Verbesina encelioides (Cav.) Benth. & Hook. Fil ex Gray as a Source of New Drugs” has been presented in different sections. The Aims and Objectives, Literature in Retrospect and Medico-ethnobotanical Background of the Verbesina encelioides has been given in the beginning whereas the Summary and Conclusions, and Bibliography have been given in the end. The Experimental part has been divided into four sections in the text. The Photographs of cultured tissues of different morphogenetic stages, tables, graphs and figures have been incorporated appropriately in the Results and Discussion. In the present study, Verbesina encelioides (Cav.) Benth. & Hook. Fil. ex Gray has been selected for its germination, tissue culture and phytochemical evaluation along with the selected biological activities, both in vivo and in vitro . The present research work is based on important medicinal plant (also known as unwanted weed) of the herbal remedies, its botanical, pharmacological, phytochemical and in vitro aspects anticipating its possible value in medicinal system.