Acquisitions are used to gain competitive advantage over other firms through gaining greater market share for improving competitiveness of companies and, entering new markets and geographies, capitalizing on economies of scale and broadening the portfolio to reduce business risk, etc. India has emerged as one of the top countries with respect to merger and acquisition deals. Indian companies have been actively involved in acquisitions in India domestically as well as internationally, as India increase its participation in M&A deals. This research study is aimed to study the Pre & Post Acquisition Comparison of Financial Performance Of Acquiring Companies [With special reference to Manufacturing sector in India (2000-2006)] by examining some pre- and post-acquisition financial ratios of these firms and to see the differences in the pre acquisition and post acquisition ratios of the firms that go for acquisitions. The results suggest that acquisitions did not experience any significant increase in profitability of the overall firms in the post acquisition period.