Mastitis, inflammation of mammary gland, is one of the most important diseases causing economic losses to dairy industry worldwide. Antibiotics are the only proven method of treatment against bovine mastitis. Presence of antibiotic residues in milk and food chain are the greatest disadvantage of use of antibiotics for the treatment of mastitis. In addition chemical teat dip residues pose another health hazards. Hence, it becomes necessary to develop new strategies for prophylaxis and treatment of mastitis. The study “ Preventive and therapeutic modalities for control of bovine mastitis” was a step in this direction. The effect of 0.2% glutaraldehyde and Aloe vera teat dip on CMT point score and SCC was evaluated in 200 lactating cows for 90 days. Therapeutic efficacy of Amoxycillin, Sulbactam, vitamin E and selenium was judged on the basis of CMT point score and SCC. Antiinflammatory potential of vitamin E and selenium was adjudged by estimation of ceruloplasmin. Antioxidant potential was adjudged by estimation of catalase and glutathione peroxidase (GSH-Px) activity. Antibacterial potential of aqueous extract P. emblica was evaluated against S. aureus.