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Principle and Theory of Novel Mucoadhesive Nasal Microemulsion

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The studies demonstrated that microemulsion system comprising Mirtazapine Capmul PG 8 (6.78% v/v), Tween 20 (31.64% v/v), PEG 400 (15.82% v/v) and distilled water (45.76% v/v) and mucoadhesive microemulsion system (0.5% HPMC K4 M based microemulsion) were optimal for intranasal delivery of Mirtazapine. The mucoadhesive microemulsion systems are transparent and stable at ambient temperature for 3 months. Results of nasal Ciliotoxicity study confirmed that developed mucoadhesive microemulsion containing Mirtazapine had no cilio toxicity. Enhanced rate and extent Mirtazapine release following application on excised nasal mucosa from Mirtazapine mucoadhesive microemulsion may help in decreasing the dose and possibly maximize the therapeutic index. The formulated Mirtazapine intranasal mucoadhesive microemulsion represents a safe and viable approach to achieving rapid-onset systemic drug levels and higher bioavailability through bypass of the liver metabolism for the management of depression.

Product Specifications
SKU :COC53037
AuthorMd. Ali Akhtar
LanguageEnglish
BindingPaperback
Number of Pages60
Publishing Year2014-01-29T00:00:00.000
ISBN9783845438757
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-06-08 00:00:00