In this research study will examines the opportunities and challenges faced by one of the private higher education institution group in Malaysia that implementing the Technological, Pedagogical, and Content Knowledge (TPACK) model. Based on the TPACK model, this study sees the sights of these interrelated questions: to what extent that the modern technologies have been utilized by the education group based on the TPACK model? What are the potential challenges faced by the academic staff in teaching and learning in ICT based? What are the opportunities that academic staff beneficial from the TPACK model? Is there any significant difference between the engineering (technology) and non engineering (non-technology) subjects’ academic staff applying ICT in their teaching and learning processes?