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Proniosome as a novel drug carrier

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Carvedilol has oral bioavailability 25% to 30% due to high first pass metabolism (80%) and presence of food decreases its absorption rate in gastrointestinal tract. Short half life of Carvedilol (4 to 6 hr) indicates need of controlled release delivery. To overcome these limitations carvedilol was incorporated in proniosome for transdermal delivery. Proniosome drug delivery was preferred due to improved stability of the system than niosomes. To optimize the formulation, various proniosome gels composed of various ratios of sorbitan fatty acid esters, polysorbates, cholesterol, lecithin were prepared by coacervation-phase separation method. Optimized formulation gave flux 3.416?g/cm2/hr up to 12 hrs. with highest permeation (65%) of carvedilol among all formulations. Penetration enhancers, non-ionic surfactants and vesicle-skin interaction may contributed to the enhanced carvedilol permeation. Thus Proniosome was found to be a promising carrier system for Carvedilol because of ease in preparation and stability for prolonged period.

Product Specifications
SKU :COC31397
AuthorHemant Patil
LanguageEnglish
BindingPaperback
Number of Pages80
Publishing Year6/22/2012
ISBN978-3659138447
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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