Skin, our ‘cosmetic’ organ when diseased or simply perceived as imperfect, can trigger profound psychological distress. A healthy normal skin is essential for a person’s physical and mental well being. It is an important aspect of their sexual attractiveness, a sense of well being and a sense of confidence. Studies shown that emotional factors are important in every aspect of skin disorder: manifestations, aggravations, responses causes and prognosis. Emotional distress counted as an integral cause of skin disease or at least an exacerbating factor leading to increased disease morbidity. It has been estimated that the effective management of at least on third of patients attending skin departments depends upon the recognition and treatment of these emotional factors. The present study was carried out to find out and to compare the level of Emotional Intelligence, Quality of Life, Coping and Self-Esteem among patients with two chronic dermatological conditions (Vitiligo and Eczema) and the results are discussed in detail.