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Pulmonary Toxicity of MgO Nanoparticles in Rats


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  • Product Description

The present study investigated the acute pulmonary toxic effects MgO nanoparticle in rats following their exposure through intratracheal instillation, and investigated the oxidative stress and anti-oxidant status in rats following exposure and also to compare these toxic effects with those of quartz particles.Intratracheal instillation method was used to exposure the nanomaterials to the rats and evaluated for various tissue damage markers like alkaline phosphatase (ALP), lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid at 1, 7, 30 days of post exposure intervals. Exposure of nanomaterials caused the dose dependant increase in ALP, LDH activity in BAL fluids of rat lungs indicated the pulmonary toxicity of these nanoparticles, which was supported by the histopathological examinations. Exposure of nanoparticles to rats produced a dose dependant decrease in the levels of TAS, Catalase SOD indicating the induction of oxidative stress.

Product Specifications
SKU :COC55051
AuthorKiranmai G. and Rama Narsimha Reddy A.
Number of Pages84
Publishing Year2014-05-06T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-06-08 00:00:00