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Pyrazoles As Potent Antimicrobial Agents

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 
Pyrazole, one of the most important classes of heterocycles, has been the topic of research for thousands of researchers all over the world because of its wide spectrum activities like anti-inflammatory, antipyretic, analgesic, antimicrobial, antihypertensive, antiglaucoma, antioxidant, antidepressent, antiarthritic, neuroprotective, antidiabetic, anticancer, antitubercular, antiviral, and antialzheimer. Pyrazole is the core structural component present in Celecoxib, Deracoxib, Pyrazofurin, Indisteron, Phenazone, Aminopyrine, Sulfinpyrazone, Allopurinol, Phenylbutazone, Famprofazone & many other agents. In the present research work, Diethyl malonate & Substituted Hydrazines were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro & 4-nitrooxy-butyl substitutions at nitrogen atom. The synthesized products were characterized by physicochemical and analytical means. Few of the synthesized derivatives showed excellent antibacterial and antifungal activities when compared to the standard Ciprofloxacin and Fluconazole.
Product Specifications
SKU :COC12198
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
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